In this case report we demonstrate the utility of CTC as a sensitive marker to detect MRD. CTCs play a crucial role in the context of MRD in colorectal cancer, offering a valuable biomarker for prognosis,

treatment monitoring, and early detection of recurrence. Despite the challenges in their clinical application, CTCs hold great potential to transform the management of CRC by enabling more personalized and effective treatment approaches. As technology advances, the integration

of CTC analysis into routine clinical practice may become a reality, significantly improving outcomes for patients with colorectal cancer.